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张文,1966年出生,华东师范大学化学系教授,博士生导师。国家自然科学基金项目:纳米过氧化物电极及其对水体中细菌的快速计数和作用机理的电化学分析研究,上海市科委纳米专项基金:纳米过氧化物高效催化电极材料及其应用于水体中大肠杆菌的快速计数研究 , 与美国EXTECH INSTRUMRNT 公司合作项目:水体中细菌电化学传感器的研究,承担上海市“曙光计划”(人才计划项目)
张文
教授(博士生导师),
化学与分子工程学院
联系电话: 021-62235761
办公时间: 周一至周五
传 真: 021-62232414
电子邮箱: wzhang@chem.ecnu.edu.cn
通讯地址: 上海市东川路500号 华东师范大学化学与分子工程学院
研究方向
生物电分析化学
荧光分析
化学修饰电极
主持的科研项目:
国家自然科学基金项目:
1.基于生物大分子模板构建荧光纳米探针用于金属离子与神经退行性疾病相关蛋白相互作用研究
2.纳米过氧化物电极及其对水体中细菌的快速计数和作用机理的电化学分析研究
3.内源性神经毒素对帕金森氏病神经原损伤毒理机制的电分析化学研究
4.半导体复合纳米材料光电分析方法在乙酰胆碱酯酶活性检测中的应用研究
5.细胞表面聚糖表达水平的电化学检测及其在肿瘤细胞分析中的应用研究
上海市科委基础研究重点项目:
6. 基于纳米氧化物催化材料的可控合成、功能化及分子识别 上海市“曙光计划”
7.神经系统损伤病理和药理的电分析化学研究
作为主要研究人员参加的科研项目:
国家自然科学基金重点项目: 神经退行性疾病分析新方法的研究
国家“九五”科技攻关项目: 国产电化学仪器的改进及新电极、传感器的研制
国家“十五”重点科技攻关项目: 纳米COD传感器及其快速在线COD电化学检测仪的研制与开发
863项目子课题: 水质自动检测系统及关键技术及集成设备研制
国家自然科学基金仪器专项: 新型COD分析方法、理论的研究及其仪器的开发
国家自然科学基金项目: 用纳米科技建立电分析化学的新原理、新方法研究
神经系统损伤病理和药理的电分析方法研究
超微传感器在心肌细胞损伤和修复中的应用研究
化学修饰电极电色效应和电色材料及其在分析仪器中的应用研究
上海市科委重点项目: 纳米氧化物紫外屏蔽性能的评价方法及其分析仪的研究与开发
纳米氧化物材料性能评估仪器的研究
近年来发表的代表性学术论文:
1.Multi-doped carbon dots with ratiometric pH sensing properties for monitoring enzyme catalytic reactions.,Chem. Comm.,2016.7.28,52(59):9247~9250
2.Photodynamic micelles for amyloid beta degradation and aggregation inhibition.,Chem. Comm.,2016.10.4,52(81):12044~12047
3.Polydopamine-Functionalized Graphene Oxide Loaded with Gold Nanostars and Doxorubicin for Combined Photothermal and Chemotherapy of Metastatic Breast Cancer,Advanced Healthcare Materials,2016.9.01,5(17):2227~2236
4.Triplex molecular beacons for sensitive recognition of melamine based on abasic-site-containing DNA and fluorescent silver nanoclusters.,Chem. Comm.,2015.5.7,51(37):7958~7961
5.A TiO2-Au–polymer hybrid system for the photoelectrochemical immunoassay of SirT. J. Mater. Chem. B,2014, 2, 1644–1652
6.Label-Free Colorimetric Protein Assay and Logic Gates Design Based on the Self-assembly of Hemin-Graphene Hybrid Nanosheet,Langmuir,2014.3.4,30(8):2144~2151
7.Lectin-Based Electrochemical Biosensor Constructed by Functionalized Carbon Nanotubes for the Competitive Assay of Glycan Expression on Living Cancer Cells Chem.Sci.‚ 2,2353-2360,2012
8.Lectin-Based Biosensor Strategy for Electrochemical Assay of Glycan Expression on Living Cancer Cells Anal. Chem.82‚ 9455–9460,2010
9.Photoelectrochemical Immunosensor Based on Au-doped TiO2 Nanotube Arrays for Detection of Alpha-Synuclein Chem. Eur. J.‚6,14439–14446,2010
10.Study on Acetylcholinesterase Inhibition Induced by Endogenous Neurotoxin with Enzyme-Semiconductor Photoelectrochemical System Chem. Comm,19,2682,2009
11.Effect of (R)-Salsolinol and N-Methyl-(R)-Salsolinol on the Balance Impairment between Dopamine and Acetylcholinein RatBrain:Involvement in Pathogenesis of Parkinson Disease Clinical Chemistry54‚705-712‚ 2008
12.Visible-light-activated photoelectrochemical biosensor for the study of acetylcholinesterase inhibition induced by endogenous neurotoxinsBiosensors and Bioelectronics‚ 45,292-299,2013
13.Three-Dimensional Ordered Macroporous (3DOM) Composite for Electrochemical Study on Acetylcholinesterase Inhibition Induced by Endogenous Neurotoxin Journal of Physical Chemistry B 36,11180-1118,2012
14.Sensitive electrochemical immunosensor for а-synuclein based on dual signal amplification using PAMAM dendrimer- encapsulated Au and enhanced gold nanoparticle labels Biosensors and Bioelectronics, 32, 224-23,2012
15.Roles of the KRAB-associated co-repressor KAP1 S473 phosphorylation in DNA damage response. Journal of Biological Chemistry‚ 287: 18937-18952.2012
16.p14ARF inhibits the functions of adenovirus E1A on coprotein Biochemical Journal 434 275-285,2011
17.A DNAsequence-specificelectrochemicalbiosensorbasedonalginicacid-coated cobalt magnetic beads for the detection of E. coli Biosensors and Bioelectronics‚ 26,3325-3330,2011
18.A new microdialysis-electrochemical device for in vivo simultaneous determination of acetylcholine and cholinein rat brain treated with N-methyl-(R)-salsolinol Biosensors and Bioelectronics 24,3594,2009
19.Development of an electrochemical immunoassay for rapid detection of E. coli using anodic strippingvoltammetrybasedonCu@Au nanoparticles as antibody labels Biosensors and Bioelectronics 24,2155–2159,2009
20.Amperometric method for rapid detection of Escherichia coli by flow injection analysis using a bismuth nano-film modified glassy carbon electrode Electrochemistry Communications 9‚ 833-838‚ 2007
21.Rapid detection of Escherichia coli by flow injection analysis coupled with amperometric method using an IrO2-Pd chemically modified electrodeElectrochemistry Communications 9‚ 2157-2162‚ 2007
22.Simultaneous determination of 5-hydroxyindoleacetic acid and 5-hydroxytryptamine in urine samples from patients with acute appendicitis by liquid chromatography using poly(bromophenol blue) film modified electrode Journal of Chromatography B‚ 846‚ 14-19‚ 2007
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